Artesunate (Dihydroartemisinin Succinate) Qing Hao

Artesunate is widely used in South East Asia and is highly effective against many strains of chloroquine resistent malaria including Plasmodium falciparum, P. berghei, P. knowlesi. It is now in use in Papua New Guinea and Vanuatu and is known to be effective against the chloroquine resistent strains in these areas.

The Ministry of Public Health of China approved Artesunate as a new antimalarial drug in 1987 and it is manufactured exclusively in China by Guilin Pharmaceutical. Artesunate is also marketed under the name of PLASMOTRIM® (Lab. Mepha, Aesch-Basle, Switzerland). Discount Pharmaceuticals sells genuine Guilin Pharmaceutical Artesunate in it's original packaging with 12 50-mg tablets in a blister-pack that seals out moisture and contamination.

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Artesunate is a natural extract of Artemisia annua, (qing hao or sweet Annie) a plant used in traditional Chinese medicine. Because Artesunate is extracted from a plant, and not produced synthetically, the drug is still difficult to obtain in many areas of the world.

Artesunate has many advantages over other antimalarial drugs. It is extremely fast acting with a fever clearance time of 20 to 24 hours. This is especially important for treatment of patients with cerebral malaria.

Artesunate is also one of the least toxic antimalarial drugs for humans and is rapidly metabolized and eliminated from the system within 45 to 60 minutes. In healthy volunteers, when the therapeutic dose was multiplied fourfold (8mg/kg) there were no serious clinical side effects, with a skin rash showing in a few patients.

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