Fansidar - Sulfadoxine
and Pyrimethamine
Sulfadoxine and pyrimethamine in combination is used to treat
malaria. The sulfadoxine and pyrimethamine combination may
cause serious side effects, and this medicine is generally
used only to treat serious malaria infections where resistant
strains of malaria reduce the usefulness of other medicines.
Many doctors will not prescribe this medicine as a preventative
against malaria because of the danger of side effects to the
blood, kidney and liver.
When travelling to a malaria danger area use all precautions
to prevent getting bitten by mosquitoes. If these fail and
you get the symptoms of malaria, your doctor may wish to prescribe
Fansidar to treat the disease.
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Cautions - warn your doctor - Don't use this medicine without a doctor's prescription.
- Allergies - Unusual or allergic reaction to sulfa medicines, furosemide (e.g., Lasix) or thiazide diuretics (water pills), oral antidiabetics (diabetes medicine you take by mouth), glaucoma medicine you take by mouth (acetazolamide [e.g., Diamox], dichlorphenamide [e.g., Daranide], methazolamide [e.g., Neptazane]), or pyrimethamine (e.g., Daraprim), any other substances, such as foods, preservatives, or dyes.
- Pregnancy - Fansidar is not recommended during pregnancy. Studies in rats have shown that sulfadoxine and pyrimethamine combination may cause birth defects and anemia. Also, women who travel to an area where there is a chance of getting malaria, and who may be taking sulfadoxine and pyrimethamine combination, should avoid becoming pregnant.
- Breast-feeding - Fansidar is not recommended for use during breast-feeding. It may cause liver problems, anemia, and other unwanted effects in nursing babies.
- Children - Fansidar should not be used in infants up to 2 months of age.
- Other medical problems - warn your doctor if you have any other medical problems, especially:
Anemia or other blood problems, Kidney disease or Liver disease, Porphyria, or Seizure disorders, such as epilepsy.
- Other medicines - interactions between medicines can have serious side effects. Warn your doctor if you are taking any of the following drugs:
Acetaminophen (e.g., Tylenol) (with long-term, high-dose use) or
Amiodarone (e.g., Cordarone) or
Anabolic steroids (nandrolone [e.g., Anabolin], oxandrolone [e.g., Anavar], oxymetholone [e.g., Anadrol], stanozolol [e.g., Winstrol]) or
Androgens (male hormones) or
Carbamazepine (e.g., Tegretol) or
Carmustine (e.g., BiCNU) or
Chloroquine (e.g., Aralen) or
Dantrolene (e.g., Dantrium) or
Daunorubicin (e.g., Cerubidine) or
Disulfiram (e.g., Antabuse) or
Divalproex (e.g., Depakote) or
Estrogens (female hormones) or
Etretinate (e.g., Tegison) or
Gold salts (medicine for arthritis) or
Hydroxychloroquine (e.g., Plaquenil) or
Naltrexone (e.g., Trexan) (with long-term, high-dose use) or
Oral contraceptives (birth control pills) containing estrogen or
Other anti-infectives by mouth or by injection (medicine for infection) or
Phenothiazines (acetophenazine [e.g., Tindal], chlorpromazine [e.g., Thorazine], fluphenazine [e.g., Prolixin], mesoridazine [e.g., Serentil], perphenazine [e.g., Trilafon], prochlorperazine [e.g., Compazine], promazine [e.g., Sparine], promethazine [e.g., Phenergan], thioridazine [e.g., Mellaril], trifluoperazine [e.g., Stelazine], triflupromazine [e.g., Vesprin], trimeprazine [e.g., Temaril]) or
Phenytoin (e.g., Dilantin) or
Valproic acid (e.g., Depakene)—Use of sulfadoxine and pyrimethamine combination with these medicines may increase the chance of side effects affecting the liver
Acetohydroxamic acid (e.g., Lithostat) or
Amphotericin B by injection (e.g., Fungizone) or
Antineoplastics (cancer medicines) or
Azathioprine (e.g., Imuran) or
Chloramphenicol (e.g., Chloromycetin) or
Colchicine or
Cyclophosphamide (e.g., Cytoxan) or
Dapsone or
Flucytosine (e.g., Ancobon) or
Furazolidone (e.g., Furoxone) or
Ganciclovir (e.g., Cytovene) or
Interferon (e.g., Intron A, Roferon-A) or
Nitrofurantoin (e.g., Furadantin) or
Primaquine or
Procainamide (e.g., Pronestyl) or
Quinidine (e.g., Quinidex) or
Quinine or
Sulfoxone (e.g., Diasone) or
Vitamin K (e.g., AquaMEPHYTON, Synkayvite) or
Zidovudine (e.g., AZT, Retrovir)—Use of sulfadoxine and pyrimethamine combination with these medicines may increase the chance of side effects affecting the blood
Antithyroid agents (medicine for overactive thyroid) or
Mercaptopurine (e.g., Purinethol) or
Methotrexate (e.g., Mexate) or
Methyldopa (e.g., Aldomet) or
Plicamycin (e.g., Mithracin)—Use of sulfadoxine and pyrimethamine combination with these medicines may increase the chance of side effects affecting the liver and the blood.
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