Use of Malarone

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Use

• Take Malarone (Atovaquone and Proguanil) at the same time each day.
• Take Malarone (Atovaquone and Proguanil) with food or with a milky drink. This will help your body absorb the maximal amount of medicine.
• If you vomit within 1 hour of taking Malarone (Atovaquone and Proguanil), take the entire dose again as soon as your stomach can tolerate it.

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Dose

The dose of Malarone (Atovaquone and Proguanil) will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of Malarone (Atovaquone and Proguanil). If your dose of Malarone (Atovaquone and Proguanil)different, do not change it unless your doctor tells you to do so.

The number of tablets that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are taking Malarone.

For oral dosage form (tablets):

For malaria prevention:

Adults—250 milligrams (mg) of atovaquone and 100 mg proguanil (1 adult strength tablet) per day, starting 1–2 days before entering malarial area and continuing for 7 days following return

Children weighing 25 pounds (11 kilograms [kg]) or more—Dosage is according to weight and will be determined by your doctor.

Children weighing less than 25 pounds (11 kg)—Use and dose must be determined by your doctor.

For malaria treatment:

Adults—1 gram of atovaquone and 400 mg of proguanil (4 adult strength tablets) once daily as a single dose taken three days in a row.

Children weighing 25 pounds (11 kg) or more—Dosage is based on body weight and must be determined by your doctor.

Children weighing less than 25 pounds (11 kg)—Use and dose must be determined by your doctor.

Missed dose

If you miss a dose of Malarone (Atovaquone and Proguanil), take it as soon as possible.

Contact your doctor as soon as possible for additional instructions since you may need additional protective measures.

Storage

To store Malarone (Atovaquone and Proguanil):

• Keep out of the reach of children.
• Store at room temperature.
• Do not store in the bathroom, near the kitchen sink, or in other damp places. heat or moisture may cause the medicine to break down.
• Do not keep outdated medicine or medicine no longer needed. Ask your health care professional how you should dispose of any medicine you do not use.
• Be sure that any discarded medicine is out of the reach of children.

Side Effects

More common - Abdominal pain; back pain; coughing; diarrhea; fever; headache; itching skin (pediatrics only); lack of or loss of strength; nausea; muscle pain; sore throat; sneezing ; vomiting

Less common - Acid or sour stomach; belching; dizziness; flu like symptoms; heartburn; indigestion; loss of appetite; stomach discomfort, upset or pain; weight loss

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

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